Piroxicam

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Piroxicam (marketed in the U.S. under the trade name Feldene) is a non-steroidal anti-inflammatory drug used to relieve the symptoms of rheumatoid, gout symptoms and osteoarthritis, postoperative pain; and act as an analgesic, especially where there is an inflammatory component.

Other brand names for Piroxicam include "Brexin," "Erazon," "Felden", "Feldoral," "Hotemin," "Pirox von ct," "Proponol," "Reumador," "Veral," and "Vurdon."

Mechanism of action piroxicam

Piroxicam is an NSAID and, as such, is a non-selective cox  inhibitor possessing both analgesic and antipyretic properties. It undergoes entero-hepatic circulation.

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Adverse effects

Piroxicam use can result in gastrointestinal toxicity, tinnitus, dizziness, headache, rash, and pruritus. The most severe adverse reactions are peptic ulceration and gastrointestinal bleeding. Approximately 30% of all patients receiving daily doses of 20 mg of piroxicam experience side effects.

Piroxicam may cause skin to become more sensitive to sunlight. Avoidance of sunlight and use of sunscreen is recommended.gouty tophi       gouty btophus    gouty tofi